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Evidence is increasing that every addiction without exception is related to problems with the brain's reward center, particularly the mesolimbic system. This the main problem regulates reward responses in getting food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both when they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in in reaction to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to shed pounds can be very effective you'll find combinations while watching FDA now awaiting approval. When dealing with weight reduction and the those who go through it you need to err to the side of caution and permit the FDA do its job and demand some investigation be done so the public recognizes the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies come in business to generate income and that they would say everything to keep people on their own medications. Researchers discovered that participants using this drug to get a year, lost excess weight within four weeks and have kept the extra weight off throughout the 56 weeks of the study. Contrave is a combination in the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs which can be made up of several active ingredient, which may make them more effective and safer. Combo-pilling is the newest fad or better yet the newest ahead under scrutiny and so it is just more publicly known although in the past, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular will be the fact that by right now there aren't any long term prescription weight loss supplements that have been licensed by the FDA apart from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications although some people might of the combinations have been rejected or have yet to be authorized by the FDA. Seizures can be a side effect with Contrave and really should not be taken in people who have seizure disorders. The drug also can raise hypertension and pulse rate, and really should not be used in individuals with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise hypertension and pulse rate and must stop used in patients with uncontrolled high blood pressure levels, along with by you are not heart-related and cerebrovascular (circulation system dysfunction impacting the brain) disease. Patients using a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients towards the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stopping smoking. Please show your support by clicking the 'Like', 'Subscribe' and 'Share' buttons seen on this page.