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The Promises Treatment Centers, estimates that between five and ten percent of the patients at his hospitals are helped by naltrexone. Those almost certainly to receive it are people who have a history of early relapse—whoever has been treated before and possess not been able to maintain sobriety for considerably more than 1 month. Using two separate drugs to shed pounds can be very effective there are combinations while watching FDA now awaiting approval. When dealing with weight loss and the those who go through it you should err to the side of caution and permit the FDA do its job and demand some research be done in order that the public recognizes the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies will be in business to generate income and that they would say everything to keep people on his or her medications. Researchers found that participants taking this drug for a year, dropped excess weight within four weeks and have kept the weight off during the entire 56 weeks of the study. Contrave is really a combination in the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs which are made up of more than one active ingredient, that might make them more effective and safer. Combo-pilling may be the newest fad or also the newest in the future under scrutiny and therefore it is just more publicly known in recent months, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular is the fact that since right now there are no long term prescription diet pills that have been authorized by the FDA apart from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications even though some of the combinations are actually rejected or have yet to be approved by the FDA. Seizures really are a side effect with Contrave and really should not be taken in those with seizure disorders. The drug also can raise hypertension and heart rate, and must not be used in people with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure levels and heartbeat and must stop used in patients with uncontrolled high blood pressure level, in addition to by you aren't heart-related and cerebrovascular (circulation system dysfunction impacting your brain) disease. Patients which has a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients for the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking. "There were no indications of depression or suicidal thoughts in trial participants," said Fujioka.